L. Mary Smith, PhD

Sr VP of Clinical Research & Development
SpringWorks Therapeutics

Mary Smith joined SpringWorks Therapeutics at launch in 2017 to lead Clinical Research and Drug Development. She brings over 20 years of research and clinical development experience from both pharmaceutical-and biotechnology-focused companies. She has experience in all stages of drug development from target discovery through all phases of clinical development and commercial launch. Most recently, Mary was the executive director of gene therapy at Bamboo Therapeutics, a wholly owned subsidiary of Pfizer where she led several key gene transfer programs for rare genetic diseases. Prior to joining Bamboo, Mary spent 12 years at United Therapeutics as the vice president of product development. In that role, she was head of biologics development in oncology, with additional responsibility for regenerative medicine and virology. Specifically, she led the multi-disciplinary team responsible for the clinical development and approval of Unituxin, the first approved immunotherapy for the treatment of high-risk neuroblastoma in the US and EU. She also managed the regenerative medicine program, which included mesenchymal stem cell therapies and lung regenerative efforts. Mary earned a PhD in microbiology/immunology from the University of New Hampshire followed by post-doctoral training at Emory University.